Bioinformatics Techniques
With the rapid development of sequencing technology, higher throughput at better quality can now be achieved at a lower cost. These data are being extensively used to decipher the mechanisms of biological systems at the most basic level However, this huge and growing amount of high-quality data, and the information that it can provide continue to created challenges for bioinformaticians to conquer.
Currently, four bioinformatics sub-groups at BGI, “Assembly”, “Mapping”, “Annotation”, and “Evolution & Comparative Genomics” are each focusing on analyzing and transferring cutting-edge technologies in their relevant fields to maximize the amount of information that can be gleaned from sequencing data.
Bioinformatics analysis methods:
- Assembly: Methods to assemble short-sequencing reads into entire and accurate reference genomes
- Mapping: Methods to compare novel sequences with a reference genome, detect variation, and analyze different expression levels
- Annotation: Methods to add biological information to raw DNA sequence, identify the structural and functional elements, and integrate and display this information at a genomic level
- Evolution & Comparative Genomics: Methods to construct phylogenetic trees, perform analyses in comparative genomics and population genetics to detect selective signals from comparative or population data